Table 2. Hypoxia-induced and HIF-dependent genes involved in cytokine-mediated signaling (GO: 19221) and type I interferon signaling (GO: 60337 and GO: 71357).

Gene name	FC*	PADI†	TCGA‡
AIM2	1.59	Yes	Yes
ANXA2	1.57	Yes	Yes
BCL6	1.93	Yes	No
CARD14	4.22	Yes	Yes
CCL5	7.96	No	Yes
CCL24	2.55	Yes	Yes
CEACAM1	12.7	No	No
CRLF1	2.65	Yes	Yes
CRLF2	3.71	Yes	Yes
CSF1R	2.44	No	Yes
DUOX2	141	Yes	Yes
EBI3	6.68	Yes	Yes
EGR1	2	Yes	No
EPO	4.28	Yes	Yes
FLRT1	2.67	Yes	No
FOS	5.45	Yes	No
HCK	6.14	Yes	Yes
ICAM1	1.72	Yes	Yes
IFIT1	5.66	Yes	No
IFIT2	11.5	Yes	Yes
IFIT3	4.4	No	Yes
IFITM1	2.03	Yes	Yes
IFITM2	1.91	Yes	No
IFNE	2.85	Yes	Yes
IFNL1	25.5	No	Yes
IL2RG	19.5	Yes	Yes
IL16	3.35	No	No
IL17RE	2.92	Yes	Yes
IRF9	2.39	Yes	No
ISG15	1.71	No	Yes
ISG20	4.33	Yes	Yes
ITGAX	5.14	Yes	Yes
ITGB2	1.83	Yes	Yes
LAMA5	1.61	Yes	No
LBP	3.38	Yes	Yes
LRRC3	4.25	Yes	Yes
MAP3K8	2.1	Yes	Yes
MAPK3	1.82	Yes	No
MUC1	10.3	Yes	No
NCAM1	1.74	No	Yes
NOD2	4.48	Yes	Yes
NUMBL	1.79	Yes	Yes
OASL	13.1	Yes	Yes
PDCD4	1.97	Yes	No
PDGFB	4.87	Yes	No
PODNL1	2.62	Yes	Yes
PRTN3	30.8	Yes	No
RHOU	2.15	Yes	No
RORA	114	Yes	No
RORC	36	Yes	No
RSAD2	27.2	Yes	Yes
RTN4RL2	2.16	Yes	No
SOCS1	1.5	Yes	Yes
STAT4	2.52	Yes	Yes
STAT6	1.52	Yes	No
TGFB1	2.07	Yes	Yes
TNFRSF8	3.17	Yes	Yes
TNFRSF14	3	Yes	No
TNFRSF25	2.91	Yes	Yes
TNFSF11	7.61	Yes	Yes
TNFSF12	1.54	Yes	No
TNFSF13	2	No	No
TNFSF14	2.02	Yes	Yes
TRADD	2.56	Yes	Yes
VEGFA	3.46	Yes	Yes
VIM	1.71	Yes	Yes
XAF1	2.14	No	Yes

*Fold change in expression in SUM159 cells exposed to 1% O₂ compared to 20% O₂.

†Hypoxic induction is also PADI4 dependent.

‡Gene expression is significantly correlated with expression of HIF signature in TCGA breast cancer database (P < 0.01, Pearson’s test).