Table 2. Sensitivity, Specificity, and Other Diagnostic Parameters of NGP27b, NGP28b, and NGP30b.
|
L. major infections vs heterologous diseases |
L.
major vs L. tropica infections |
|||||
|---|---|---|---|---|---|---|
| NG27b (%) | NGP28b (%) | NGP30b (%) | NG27b (%) | NGP28b (%) | NGP30b (%) | |
| Original Valuesa | ||||||
| sensitivityb | 95.3 | 88.0 | 91.0 | 95.3 | 88.0 | 91.0 |
| specificityc | 82.8 | 80.0 | 80.0 | 93.8 | 88.2 | 79.0 |
| FPRd | 17.2 | 20.0 | 20.0 | 6.2 | 11.8 | 21.0 |
| PPVe | 94.2 | 93.1 | 93.1 | 98.8 | 97.6 | 95.3 |
| NPVf | 85.7 | 68.6 | 75.0 | 79.0 | 57.7 | 65.2 |
| Post-TG-ROC Analysisg | ||||||
| sensitivity | 94.2 | 83.5 | 88.0 | 95.3 | 88.0 | 88.0 |
| specificity | 85.7 | 92.3 | 100.0 | 100.0 | 88.2 | 93.8 |
| FPR | 14.3 | 7.7 | 0.0 | 0.0 | 11.8 | 6.2 |
| PPV | 95.3 | 92.0 | 100.0 | 100.0 | 96.4 | 98.8 |
| NPV | 82.8 | 60.0 | 75.0 | 75.0 | 48.4 | 57.7 |
a
Values calculated based on the initial cutoff value (Ci ; titer = 1.000) (Figure 2a), as described in the Supporting Information (“Chemiluminescent ELISA”).
b
Sensitivity = true positive (TP)/TP + false negative (FN).
c
Specificity = true negative (TN)/TN + false positive (FP).
d
False-positive rate = 100 – specificity.
e
Positive predictive value = TP/TP + FP.
f
Negative predictive value = TN/TN + FN.
g
Values calculated based on the TG-ROC analysis (Figure 2c; Tables S1 and S2).