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Structure of the reduced gadoxetate PBPK model. Continuous arrows represent the mass exchange within the system, while dashed arrows represent gadoxetate elimination. Subscripts co, rob, spl, splan, h, and r represent the cardiac output, ROB, spleen, splanchnic organs, hepatic, and renal, respectively. CL, Q, and PS represent the clearance processes, the blood flows, and the permeability surface product, respectively.
