Table 2. Parameters Derived from the Mechanistic Modeling of Gadoxetate Kinetic In Vitro Data in Plated Rat Hepatocytes.
| animal |
||||||
|---|---|---|---|---|---|---|
| parameter | 1 | 2 | 3 | 4 | average | CV % |
| Vmax [pmol/min/106 cells] | 350.4 | 370.9 | 221.7 | 368.8 | 327.95 | 22% |
| Km,u [μM] | 114.1 | 115.8 | 79.8 | 115.3 | 106.25 | 17% |
| CLpassive,u [μL/min/106 cells] | 0.091 | 0.202 | 0.274 | 0.203 | 0.193 | 39% |
| fu,liv,cell | 0.759 | 0.709 | 0.418 | 0.704 | 0.648 | 24% |
| CLactive,ua [μL/min/106 cells] | 3.07 | 3.20 | 2.78 | 3.20 | 3.06 | 6% |
| maximum % activeb | 97 | 94 | 91 | 94 | 94 | 3 |
| % passivec | 3 | 6 | 9 | 6 | 6 | 41 |
a
Vmax/Km,u.
b
CLactive,u/(CLactive,u + CLpassive,u).
c
CLpassive,u/(CLactive,u + CLpassive,u).