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. 2021 Aug 12;12:711902. doi: 10.3389/fendo.2021.711902

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Copyright © 2021 Li, Zhang, Zheng, Tian, Zhang, Tan, Li, Zhang and Huang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exosomes promoted ovarian proliferation by regulating the Hippo pathway in POI mice. (A) Expression of PCNA was measured by immunofluorescence staining in the different groups. Scale bar: 50 μm and 200 μm. Expression of Ki67 was measured by (B) immunohistochemical staining and (C) immunofluorescence staining in the three groups. Scale bar: 20 μm and 50 μm. (D) Representative immunoblots of biomarkers of proliferation and the Hippo pathway, using GAPDH as reference. Quantification of protein expression revealed that exosomal treatment elevated the expression levels of (E) FSHR, (F) PCNA, (G) YAP1, (I) TEAD1, and (J) TAZ, and suppressed the expression of (H) p-YAP and (K) MST1. Data are presented as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ns, no significance. Data are representative of three independent experiments in each group.