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. 2021 Jul 21;46(5):575–593. doi: 10.1007/s13318-021-00700-5

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© The Author(s) 2021, corrected publication 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 9 — a Schematic representation of polymer (pMeOx-b-pBuOx-b-pMeOx) as best solubilizer for mitotane. b Chemical structure of mitotane. c Long-term stability of mitotane formulation depending on mitotane feed concentration (polymer 10 g/l, mitotane 2–10 g/l). Data are given as means ± SD (n = 3). d Schematic illustration of thin film hydration method used for formulation development. e Cell viability and corresponding IC₅₀ values of mitotane dissolved in ethanol (red) and as micelle formulation (blue) in NCI-H295R monolayer after incubation for 24 and 48 h (left vertical panel) and 3D tumor spheroids at 24 h and 48 (right vertical panel) (n = 3 ± SD). Modified with permission from [111]