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. 2020 Aug 18;44(3):1713–1720. doi: 10.1007/s10143-020-01369-1

Table 1.

Correlations between clinical and histopathological variables and progression. Male gender, the extent of resection, and high-grade histology were found to correlate with prognosis in both univariate (left column) and multivariate (right column) analyses. To avoid collinearity, Simpson grade and the dichotomized extent of resection were not put into the multivariate model at the same time. Of the latter, results from multivariate analyses are given in the manuscript text

Variable HR1, 95%CI2 p value3 HR, 95%CI p value4
Age 1.01, .99–1.02 .368 1.01, .99–1.02 .443
Sex
  Female (ref5) vs male 2.24, 1.54–3.24 < .001 1.63, 1.10–2.40 .015
Tumor location
  Non-skull base (ref) vs skull base 1.31, .90–1.89 .158 1.23, .83–1.83 .303
WHO grade
  Grade I (ref) vs high-grade histology 4.44, 3.03–6.50 < .001 4.46, 2.96–6.72 <.001
Simpson grade
  I ref ref
  II 1.73, 1.04–2.87 .035 1.74, 1.04–2.94 .036
  III 1.85, .99–3.43 .053 1.76, .93–3.33 .080
  IV 3.23, 1.74–6.0 < .001 3.86, 2.01–7.42 < .001
  V 5.70, .76–42.51 .090 3.35, .44–25.64 .245
Dichotomized scales
  Simpson grade I/II (ref) vs ≥ III 1.68, 1.14–2.48 .008 n/a6
  Simpson grade I–III (ref) vs ≥ IV 2.20, 1.36–3.56 .001 n/a

n/a not applicable

1Hazard ratio

2Confidence interval

3Univariate backward Wald p value

4Multivariate backward Wald p value

5Reference