Fig. 12.

Effect of 3,4-Dimethylthiolane-type sulfide (onionin A₁: ONA) on tumor progression and metastasis in tumor injected mice Onionin A₁ (ONA) (20 mg/kg) was administered orally before and after the subcutaneous implantation of LM8 cells in the C3H mice (n = 20, each group) for 3 weeks, followed by determination of the subcutaneous tumor weight and presence of lung metastasis (A). As a murine ovarian cancer model, C57B6 mice were injected in the right ovary with iMOC cells and were administered ONA (20 mg/kg) for 3 week, followed by determination of the subcutaneous tumor weight (B)