Fig. 4. De novo extraction from whole-genome sequencing data produces 10 structural variant (SV) signatures in 752 newly diagnosed multiple myeloma samples.

The 10 SV signatures extracted comprise varying contribution across the 32-SV-feature matrix. SV-SIG1, SV- SIG2, and SV-SIG3 contain clustered SV features and are associated with chromothripsis. The remainder of the signatures consist of non-clustered events. (SV-SIG: structural variant signature).