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. 2021 Aug 27;12:5172. doi: 10.1038/s41467-021-25469-8

Fig. 5. Copy number (CN) signatures in newly diagnosed multiple myeloma are strongly predictive of chromothripsis.

Fig. 5

Receiver operating curve (ROC) for the prediction of chromothripsis from CoMMpass whole-genome sequencing (WGS) data (n = 752) from a structural variant (SV) and CN signature analysis, b ShatterSeek features, c SV signatures alone and d CN signatures alone. e ROC for the prediction of chromothripsis from the validation set of other hematological cancers (n = 235). f ROC for the prediction of chromothripsis from the newly diagnosed multiple myeloma subset of the validation WGS (n = 34). Blue lines represent individual ROC (from 10-fold cross validation in (a–e) and 5-fold validation in (f), red lines represent the mean of individual ROC, AUC: mean area-under-the-curve.