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. 2021 Aug 27;12:5172. doi: 10.1038/s41467-021-25469-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Progression-free survival (PFS) probability in the CoMMpass dataset according to high (blue) or low (red) CN-prediction score for chromothripsis (CN_pred). b Overall survival (OS) probability in the CoMMpass dataset according to high (blue) or low (red) CN_pred. c Multivariate analysis of the effect of CN_pred on PFS after correction for International Staging Score (ISS), age, Eastern Cooperative Oncology Group (ECOG) score, and APOBEC mutational activity. d Multivariate analysis of the effect of CN_pred on OS after correction for the same factors. All p-values for Kaplan–Meier curves were generated according to a 2-sided log-rank test. Multivariate analysis was performed by the Cox proportional hazards model with p-values according to a 2-sided Wald test. Data are presented as median values ± 95% confidence interval.