Fig. 8. Copy number (CN) signatures extracted from whole-exome sequencing (WES) in newly diagnosed multiple myeloma are highly predictive of clinical outcomes.

a Progression-free survival (PFS) probability in the CoMMpass dataset according to high (blue) or low (red) exome CN-prediction score (eCN_pred) for chromothripsis. b Overall survival (OS) probability in the CoMMpass dataset according to high (blue) or low (red) eCN_pred. c Multivariate analysis of the effect of eCN_pred on PFS after correction for International Staging Score (ISS), age and APOBEC mutational activity. d Multivariate analysis of the effect of eCN_pred on OS after correction for the same factors. All p-values for Kaplan–Meier curves were generated according to a 2-sided log-rank test. Multivariate analysis was performed by the Cox proportional hazards model with p-values according to a 2-sided Wald test. Data are presented as median values ± 95% confidence interval.