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. 2021 Mar 15;15(9):2574–2590. doi: 10.1038/s41396-021-00937-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Plot of Clostridiales abundance and butyrate concentrations with respect to age. Six representative subjects are presented (see Fig. S5A for all subjects). Blue and orange dotted vertical lines represent the initiation of solid food and cessation of breastfeeding, respectively. B Pathway for butyrate production [35]. C Age-dependent heatmap of Clostridiales phylotypes and their potent butyrate production. The top 40 Clostridiales phylotypes are shown. Left tree represents the taxonomic relationship based on 16S rRNA sequences. Right figure is a summary of the presence of genes for butyrate production (see Fig. S6B). Phylotypes mentioned in the text are highlighted in bold.