Table 1.
Characteristic of patients undergone different diagnostic tests.
| Characteristics | HE4 (studies = 25) | CA125 (studies = 26) | ROMA-all (studies = 22) | ROMA (pre-menopause) (studies = 24 ) | ROMA (post-menopause) (studies = 26) |
|---|---|---|---|---|---|
| Ovarian cases | 2233 | 2315 | 2281 | 902 | 1902 |
| Healthy control | 5682 | 5875 | 5068 | 4351 | 2144 |
| Weighted average age (years)-cases | 53.7 | 53.5 | 54.5 | Not reported | |
| Weighted average age (years)—control | 43.2 | 43.5 | 43.1 | Not reported | |
| Stage specific distribution (%) | |||||
| I | 290 (13.0) | 294 (12.7) | 320 (14.0) | Not reported | |
| II | 93 (4.2) | 101 (4.4) | 101 (4.4) | ||
| III | 691 (30.9) | 721 (31.1) | 754 (33.1) | ||
| IV | 315 (14.1) | 342 (14.8) | 265 (11.6) | ||
| Not available | 844 (37.8) | 857 (37.0) | 841 (36.9) | ||
| Type specific distribution (%) | |||||
| Serous | 799 (35.8) | 819 (35.4) | 798 (35.0) | Not reported | |
| Mucinous | 150 (6.7) | 150 (6.5) | 129 (5.7) | ||
| Endometroid | 263 (11.8) | 253 (10.9) | 242 (10.6) | ||
| Clear | 99 (4.4) | 95 (4.1) | 94 (4.0) | ||
| Mixed | 38 (1.7) | 38 (1.6) | 38 (1.7) | ||
| Others | 13 (0.6) | 13 (0.6) | 11 (0.5) | ||
| Not available | 871 (39.0) | 947 (40.9) | 969 (42.5) | ||
Human epididymis secretory protein 4 (HE4), Cancer antigen (CA125) and Risk of Ovarian Malignancy Algorithm (ROMA).