Table 2.

Comparison of diagnostic measures by three serum markers.

Procedure	Statistics (95% CI)	Name of marker		ROMA
		HE4	CA 125	ROMA All	ROMA Pre-Menopause	ROMA Post-Menopause
	Sensitivity	0.73 (0.71–0.75)	0.84 (0.82–0.85)	0.86 (0.84–0.87)	0.80 (0.78–0.83)	0.88 (0.86–0.89)
	Specificity	0.90 (0.89–0.91)	0.73 (0.72–0.74)	0.79 (0.78–0.80)	0.80 (0.79–0.82)	0.83 (0.81–0.84)
Random effect	LR + ve	10.61 (7.28–15.45)	2.91 (2.47–3.42)	4.66 (3.41–6.35)	4.59 (3.41–6.18)	5.86 (4.35–7.89)
	LR –ve	0.27 (0.21–0.34)	0.23 (0.19–0.29)	0.18 (0.13–0.24)	0.26 (0.21–0.33)	0.15 (0.12–0.19)
	Diagnostic Odds ratio	41.03 (27.96–60.21)	13.44 (9.97–18.13)	27.48 (18.70–40.38)	18.93 (13.04–27.48)	44.04 (31.27–62.03)
	Tau-square (%)	67.71	41.90	65.74	51.61	36.19
	Cochrane-Q	107.60 (P = 0.001)	106.84 (P = 0.001)	117.96 (P = 0.001)	67.63 (P = 0.001)	49.54 (P = 0.002)
	Spearman’s correlation	0.49 (P = 0.013)	0.12 (P = 0.576)	0.30 (P = 0.183)	0.18 (P = 0.390)	0.46 (P = 0.019)
Fixed effect	LR + ve	7.73 (7.05–8.46)	2.98 (2.84–3.12)	4.07 (3.84–4.32)	4.30 (3.97–4.66)	4.64 (4.19–5.12)
	LR –ve	0.30 (0.28–0.32)	0.23 (0.21–0.25)	0.18 (0.16–0.20)	0.25 (0.22–0.29)	0.15 (0.13–0.17)
	Diagnostic Odds ratio	37.31 (31.63–44.01)	13.57 (11.93–15.42)	26.24 (22.46–30.65)	19.09 (15.61–23.35)	42.42 (33.78–53.27)
	Tau-square	77.70	76.60	82.20	66.00	49.50
	Cochrane-Q	107.60 (P = 0.001)	106.84 (P = 0.001)	117.96 (P = 0.001)	67.63 (P = 0.001)	49.54 (P = 0.002)
Symmetrical ROC (SROC)	AUC (SE) Q* index (SE)	0.91 (0.01) 0.84 (0.01)	0.86 (0.02) 0.79 (0.02)	0.91 (0.01) 0.84 (0.01)	0.88 (0.01) 0.81 (0.01)	0.94 (0.01) 0.87 (0.01)

Human epididymis secretory protein 4 (HE4), Cancer antigen (CA125) and Risk of Ovarian Malignancy Algorithm (ROMA). Positive Likelihood ratio (LR + ve), Negative Likelihood ratio (LR–ve), Standard error (SE).