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. 2021 Aug 27;11:17302. doi: 10.1038/s41598-021-96526-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolic activity (a) and total cell number per area determined by counting the cells on micrographs (b). The percentage of alamarBlue reduction in the supernatant refers to a 100% reduced control. Data are presented as mean values ± SEM (data collected on 6 biomaterial discs). Statistically significant differences between the different biomaterial groups were marked with brackets above the corresponding bars. “*” marks statistically significant differences between day 1 and 3, “+” between day 3 and day 7 and “#” between day 1 and day 7.