Table 5.
Biomarker parameters recorded at time of admission (baseline) and at time of discharge from hospital (endpoint)
| Arm I: Placebo Mean (SD) |
Arm II: NVK Mean (SD) |
Arm III: KSK Mean (SD) |
P value | |
|---|---|---|---|---|
|
IL 6 baseline (n=38, 39, 34) |
7.5 (4.4) | 5.7 (4.2) | 7.1 (4.0) | 0.09 |
|
IL 6 endpoint (n=38, 39, 38) |
4.0 (2.9) | 2.6 (2.5) | 2.2 (1.3) | 0.02 |
|
LDH baseline (n=26, 25, 22) |
17.2 (3.5) | 16.6 (4.6) | 17.3 (5.8) | 0.61 |
|
LDH endpoint (n=24, 17, 13) |
17.4 (5.6) | 17.3 (3.9) | 13.2 (5.6) | 0.10 |
|
Ferritin baseline (n=26, 25, 21) |
10.5 (4.5) | 11.7 (5.3) | 13.2 (5.8) | 0.25 |
|
Ferritin endpoint (n=23, 16, 11) |
11.4 (5.0) | 11.0 (5.7) | 10.6 (5.3) | 0.95 |
|
D dimer baseline (n=26, 21, 13) |
0.9 (0.7) | 1.9 (3.6) | 2.7 (6.8) | 0.79 |
|
D dimer endpoint (n=16, 15, 7) |
2.6 (4.8) | 1.6 (2.6) | 3.7 (7.5) | 0.53 |
|
CRP baseline (n=24, 25, 22) |
3.5 (2.8) | 3.0 (2.4) | 2.6 (1.5) | 0.84 |
|
CRP endpoint (n=22, 19, 15) |
3.9 (3.2) | 2.5 (1.6) | 3.1 (4.7) | 0.26 |
Units: IL 6, picogram per milliter (pg/mL); LDH, units per liter (U/L); Ferritin, micrograms per liter (mg/L); D-dimer, nanograms per milliliter (ng/mL); CRP, milligrams per decilitre (mg/dL)