Figure 5.

Schematic representation of the encapsidation indicating a process of liquid–liquid phase separation (LLPS). The interaction between capsid protein (green circles) and the viral genome (red) results in a liquid–liquid phase transition to form the NC structure (light green droplet). These droplets associate with the ER membranes during the viral particle formation stabilizing an NC–membrane interaction for final viral particle budding into the ER lumen. ER, endoplasmic reticulum; NC, nucleocapsid.