Figure 5.

Interactions of antidepressants with placental efflux transporters in dually perfused rat term placenta in closed experimental setup. Reductions in [³H]sertraline and [³H]paroxetine concentrations in the fetal circulation were observed, suggesting active efflux to the maternal circulation (a,b). However, these reductions were not inhibited by addition of GF 120918 (2 µM), a model P-gp and BCRP inhibitor. [³H]citalopram concentrations were stable throughout the perfusion experiment (c) indicative of passive transport across the placenta. Insets show ratios of concentrations of tested drugs in fetal and maternal circulations (F/M ratios) in the absence and presence of GF 120918 (2 µM), at the final sampling point (40 min). Data are means ± SD; n > 3.