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. 2021 Aug 20;13(8):1306. doi: 10.3390/pharmaceutics13081306

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Novel perspectives of antidepressants’ effect on serotonin homeostasis in the placenta. Serotonin reuptake inhibitors tested in our study (citalopram, sertraline, paroxetine, fluoxetine, fluvoxamine, venlafaxine) block the activity of both SERT and OCT3 transporters localized on the microvillous and basal membrane, respectively. Antidepressants thus compromise placental clearance of serotonin from maternal and fetal circulations, resulting in inadequate serotonin concentrations in the fetoplacental unit. By this effect, these drugs may disrupt proper placental and/or fetal development and programming. ADs—antidepressants.