Table 2.
DLS analysis of DT (DPPC:TEL), DC (DPPC:Chol) and DD (DPPC:DOPE). Curcumin-loaded liposomes nebulised via vibrating-mesh (PARI VELOX®) and air-jet nebulisation (PARI BOY® SX) were compared with each other, respectively. Unnebulised curcumin-loaded liposomes were used as control. Values of particle size represent the distribution by intensity. Independent formulations were used to measure the triplicates and all results were expressed as mean ± standard deviation.
| Lipid Compositions |
Size (nm) ± SD |
PdI 1 ± SD | ζ-Potential (mV) ± SD |
|
|---|---|---|---|---|
| DT | 129.7 ± 3.2 | 0.19 ± 0.08 | −13.53 ± 2.42 | |
| CUR-liposomes | DC DD |
109.4 ± 2.4 94.4 ± 5.9 |
0.14 ± 0.09 0.26 ± 0.11 |
−5.61 ± 0.79 −2.97 ± 0.81 |
| Nebulised (PARI VELOX®) CUR-liposomes |
DT DC DD |
131.1 ± 3.0 116.4 ± 3.2 99.1 ± 5.2 |
0.21 ± 0.06 0.18 ± 0.07 0.30 ± 0.09 |
−16.33 ± 1.95 −3.74 ± 0.64 −2.86 ± 0.59 |
| Nebulised (PARI BOY® SX) CUR-liposomes |
DT DC DD |
129.5 ± 2.8 113.3 ± 3.5 100.7 ± 4.7 |
0.20 ± 0.08 0.21 ± 0.09 0.32 ± 0.08 |
−15.54 ± 2.13 −5.13 ± 0.92 −3.11 ± 0.76 |
| Lyophilised & nebulised (VELOX®) CUR-liposomes |
DT DC DD |
149.6 ± 4.1 127.7 ± 4.8 132.1 ± 5.1 |
0.46 ± 0.10 0.47 ± 0.13 0.57 ± 0.13 |
−37.89 ± 4.43 −11.47 ± 2.38 −9.62 ± 2.09 |
1 Polydispersity index.