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. 2021 Aug 20;13(8):1305. doi: 10.3390/pharmaceutics13081305

Table 3.

Summary of analysis of variance (ANOVA) of Plackett–Burman screening design batches for ETF/DEA flux ratios.

Source DF Adj. SS Adj. MS F-Value p-Value
Prob > F
Model 8 555.532 69.441 163.44 <0.001
 Linear 7 552.311 78.902 185.70 <0.001
  Isopropanol Conc. (%) 1 435.510 435.510 1025.01 <0.001
  Temperature (°C) 1 15.368 15.368 36.17 <0.001
  Stirring Speed (rpm) 1 42.711 42.711 100.52 <0.001
  Medium pH 1 14.470 14.470 34.06 <0.001
  Medium Degassing 1 43.394 43.394 102.13 <0.001
  Stirring While Sampling 1 0.384 0.384 0.90 0.345
  Replacement Medium Volume (mL) 1 0.474 0.474 1.12 0.294
 Curvature 1 0.031 0.031 0.07 0.788
Error 72 30.592 0.425
Total 80 586.123

DF—Total Degrees of Freedom; Adj. SS—Adjusted Sum of Squares; Adj. MS—Adjusted Mean Squares; The F-value is the test statistic used to determine whether the term is associated with the response; The p-value is a probability that measures the evidence against the null hypothesis. Lower probabilities provide stronger evidence against the null hypothesis. 95% significant values are given in bold.