Table 2.
Prognostic factors for HCC recurrence.
| Univariate | Multivariate | ||||
|---|---|---|---|---|---|
| Variable | Comparison | HR (95% CI) | p-Value | HR (95% CI) | p-Value |
| Age (years) | Per one-year increase | 1.016 (1.006–1.027) | 0.003 | 1.023 (1.003–1.042) | 0.020 |
| Sex | Male vs. Female | 1.201 (0.858–1.908) | 0.286 | ||
| DM | Yes vs. No | 1.492 (1.166–1.908) | 0.001 | ||
| Hypertension | Yes vs. No | 1.148 (0.907–1.454) | 0.251 | ||
| Alcohol drinking | Current vs. Never/Past | 1.106 (0.863–1.418) | 0.426 | ||
| Smoking | Current vs. Never/Past | 1.168 (0.924–1.477) | 0.195 | ||
| HCC family history | Yes vs. No | 1.153 (0.864–1.539) | 0. 332 | ||
| HBeAg | Positive vs. Negative | 1.278 (0.889–1.839) | 0.186 | ||
| HBV DNA (IU/mL) | Detectable vs. Undetectable | 1.071 (0.737–1.555) | 0.720 | ||
| NUCs treatment | Yes vs. No | 1.056 (0.837–1.333) | 0.664 | ||
| AST (U/L) | >40 vs. ≤40 | 1.462 (1.142–1.874) | 0.003 | ||
| ALT (U/L) | >40 vs. ≤40 | 1.301 (1.029–1.647) | 0.028 | ||
| Platelets (109/L) | <150 vs. ≥150 | 1.524 (1.208–1.922) | <0.001 | ||
| AFP (ng/mL) | >200 vs. ≤200 | 1.028 (0.776–1.361) | 0.847 | ||
| Albumin (mg/dL) | Per 1 unit decrease | 1.295 (1.093–1.757) | 0.007 | ||
| Child–Pugh class | B vs. A | 1.209 (0.387–3.775) | 0.744 | ||
| ALBI grade | II/III vs. I | 1.166 (0.878–1.548) | 0.289 | ||
| Liver cirrhosis | Yes vs. No | 2.117 (1.673–2.679) | <0.001 | 2.178 (1.146–3.282) | <0.001 |
| BCLC stage | A vs. 0 | 1.615 (1.195–2.182) | 0.002 | ||
| Tumor no. | Multiple vs. Single | 1.339 (0.985–1.819) | 0.062 | ||
| Tumor diameter (cm) | Per 1 cm increase | 1.218 (1.090–1.361) | <0.001 | ||
| Histological grade | Poor/Moderate vs. Well | 1.230 (0.908–1.667) | 0.181 | ||
| Microvascular invasion | Yes vs. No | 1.150 (0.902–1.467) | 0.258 | ||
| Capsule invasion | Yes vs. No | 1.022 (0.766–1.363) | 0.883 | ||
| Satellite nodules | Yes vs. No | 2.418 (1.437–4.060) | 0.001 | ||
| MAFLD | Yes vs. No | 0.902 (0.719–1.131) | 0.370 | ||
Abbreviations: HR, hazard ratio; CI, confidence interval; BMI, body mass index; ETV, entecavir; TDF, tenofovir disoproxil fumarate; AST, aspartate aminotransferase; ALT, alanine aminotransferase; AFP, alpha fetoprotein; ALBI, albumin-bilirubin; HCC, hepatocellular carcinoma; HBeAg, hepatitis B e antigen; NUCs, nucleos(t)ide analogs.