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. 2021 Aug 15;26(16):4936. doi: 10.3390/molecules26164936

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of in vitro release of DOX from uncoated liposomes and SF-LPs in PBS, pH 7.4 at 37 °C, over two periods. (A) Short-term release over the first 4 h (240 min) of drug release. (B) Long-term release over 21 days (500 h). The long-term release profiles were fitted with the Korsmeyer–Peppas kinetic model, M_t/M_∞ = K_kp × tⁿ, where M_∞ is the amount of drug at the equilibrium state, M_t is the amount of drug released over time t, K_kp is the constant incorporating structural and geometrical characteristics of the nanocarrier, and n is the diffusional exponent or drug release that determines drug release mechanism. The fitting curves demonstrate that the release behavior of DOX from uncoated liposomes and SF-LPs were governed by Fickian diffusion mechanism as a matrix system.