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. 2021 Aug 19;13(8):1295. doi: 10.3390/pharmaceutics13081295

Figure 7.

Figure 7

Photodynamic effects of Ru-complex in colorectal cancer and normal cells. (A) Chemical structure of 14a and 14b. (B) Ru-complexes having photosensitizing properties selectively kill CRC cells. Ru-complex with photosensitizing property can selectively enter cancer cells, and with the presence of light irradiation, O2 is converted into 1O2. 1O2 interact with DNA to mediate cell death via photocleavage activity. Tryptophan receptor: TfR, Oxygen: O2, Singlet oxygen: 1O2.