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Induction of E2-dependent transcriptional activity of the ERα-ERβ heterodimer by SRC-1. Cos-1 cells were cotransfected with E/GRE2TKLuc and 50 ng of either ERα-ERβGR or HE82-ERβ and 100 ng of SRC-1 expression vector. The cells were treated with a control (0.1% ethanol) or 10 nM E2. The effect of SRC-1 on response to E2 is also indicated. Results are expressed as the response over basal levels in the absence of a ligand.
