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. 2021 Aug 12;26(16):4887. doi: 10.3390/molecules26164887

Table 5.

Function of other polyphenols and in promotion of muscle health and prevention of muscle atrophy.

Compounds/Derivatives Model Effects References
Others Curcumin LPS—induced muscle atrophy in mice Prevented muscle loss
inhibited atrogin-1 expression and P38 activation
[150]
Curcumin COPD-induced rat model Attenuated muscle fiber atrophy
improved mitochondrial structure
decreased oxidative stress and inflammation
[151]
Curcumin STZ-induced diabetic mice model Prevented skeletal muscle atrophy
Inhibited ubiquitin ligases expression
[152]
Curcumin CKD-induced muscle atrophy in mice Protected body weight and fiber CSA
Increased mitochondrial biogenesis
Suppressed oxidative stress and GSK-3β expression
[153]
Curcumin c3 complex Human skeletal myoblast cell and tumor-induced muscle wasting in vivo Prevented cachexia-induced muscle wasting
Decreased 20S proteasome activity
Improved muscle characteristics
[154]
Curcumin Hypoxia induced muscle atrophy of rat Reduced muscle protein degradation
Increased myofibrillar proliferation and differentiation
reduced oxidative stress
[155]
Curcumin Tail suspension-induced muscle atrophy in rat Prevented loss of muscle mass
promotes Grp94 protein expression
[156]
Curcumin Immobilization-induced muscle atrophy in rats Improved recovery during reloading
prevented proteasome chymotrypsin-like activity
and caspase-9-associated apoptosome activity
[157].
Curcumin HLS-induced muscle atrophy in mice Attenuated muscle proteolysis
elicited Sirt1 activity
[158]
Curcumin with fish oil HLS-induced atrophy in mice Mitigated unloading-induced decrease in fiber CSA
Increased HSP70 level
phosphorylated Akt and p70S6K
Decreased Nox2 level
[159]