Table 5.
Compounds/Derivatives | Model | Effects | References | |
---|---|---|---|---|
Others | Curcumin | LPS—induced muscle atrophy in mice | Prevented muscle loss inhibited atrogin-1 expression and P38 activation |
[150] |
Curcumin | COPD-induced rat model | Attenuated muscle fiber atrophy improved mitochondrial structure decreased oxidative stress and inflammation |
[151] | |
Curcumin | STZ-induced diabetic mice model | Prevented skeletal muscle atrophy Inhibited ubiquitin ligases expression |
[152] | |
Curcumin | CKD-induced muscle atrophy in mice | Protected body weight and fiber CSA Increased mitochondrial biogenesis Suppressed oxidative stress and GSK-3β expression |
[153] | |
Curcumin c3 complex | Human skeletal myoblast cell and tumor-induced muscle wasting in vivo | Prevented cachexia-induced muscle wasting Decreased 20S proteasome activity Improved muscle characteristics |
[154] | |
Curcumin | Hypoxia induced muscle atrophy of rat | Reduced muscle protein degradation Increased myofibrillar proliferation and differentiation reduced oxidative stress |
[155] | |
Curcumin | Tail suspension-induced muscle atrophy in rat | Prevented loss of muscle mass promotes Grp94 protein expression |
[156] | |
Curcumin | Immobilization-induced muscle atrophy in rats | Improved recovery during reloading prevented proteasome chymotrypsin-like activity and caspase-9-associated apoptosome activity |
[157]. | |
Curcumin | HLS-induced muscle atrophy in mice | Attenuated muscle proteolysis elicited Sirt1 activity |
[158] | |
Curcumin with fish oil | HLS-induced atrophy in mice | Mitigated unloading-induced decrease in fiber CSA Increased HSP70 level phosphorylated Akt and p70S6K Decreased Nox2 level |
[159] |