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. 2021 Aug 13;10(8):1026. doi: 10.3390/pathogens10081026

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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HPV community structures between LSIL and HSIL. 3D-Principal Coordinate Analysis (PCoA) plots of samples (n = 155) in distinct colors before (A) and after (B) grouping by cytological category. After grouping by LSIL and HSIL, HPV-16, -35, -39 were identified as the three most influential genotypes (vectors) in both HPV communities. Dissimilarity between the two HPV communities was HPV-16 (PCoA 1) being the most influential genotype in HSIL versus HPV-39 for LSIL (PCoA 3). β-diversity was measured by Bray-Curtis index (PERMANOVA, p < 0.05).