Figure 3.

Association between patient score on PC4, clinical characteristics (top graph) and patient reported outcomes (bottom graph) in multivariable regression models. We found that higher plasma concentrations of the metabolites in PC4 were associated with both a decreased probability of adverse clinical characteristics and improved patient reported health status in all domains other than arrhythmia. Models for clinical outcomes (other than worsening quality of life) are adjusted for clinical covariates. Worsening quality of life is adjusted for age and TGA, anxiety/depression score, quality of life score, symptoms and total score are adjusted for the presence of non-cardiac diagnoses and the symptoms score is further adjusted for the sex of the participant. Abbreviations: CI—confidence interval; O2—oxygen; OR—odds ratio; QOL—quality of life; SOB—shortness of breath.