Table 2.
Significantly impacted pathways stratified by category of ACHD diagnoses (*** FDR p < 0.01, ** FDR 0.01 < p < 0.05, * FDR 0.05 < p < 0.10, no * FDR > 0.10).
| Significantly Impacted Pathways | |
|---|---|
| All congenital heart disease | Septal |
| Aminoacyl-tRNA biosynthesis *** | Aminoacyl-tRNA biosynthesis * |
| Histidine metabolism *** | Histidine metabolism * |
| Arginine biosynthesis ** | Arginine and proline metabolism |
| Arginine and proline metabolism * | Arginine biosynthesis |
| Phenylalanine, tyrosine and tryptophan biosynthesis * | beta-Alanine metabolism |
| Galactose metabolism | |
| Alanine, aspartate and glutamate metabolism | Single ventricle |
| D-Glutamine and D-glutamate metabolism | Taurine and hypotaurine metabolism |
| Taurine and hypotaurine metabolism | Sphingolipid metabolism |
| beta-Alanine metabolism | Linoleic acid metabolism |
| Phenylalanine metabolism | Cysteine and methionine metabolism |
| Systemic right ventricle | Other |
| Alanine, aspartate and glutamate metabolism *** | Histidine metabolism ** |
| Histidine metabolism *** | Aminoacyl-tRNA biosynthesis * |
| Aminoacyl-tRNA biosynthesis ** | Pantothenate and CoA biosynthesis |
| Arginine biosynthesis ** | beta-Alanine metabolism |
| Arginine and proline metabolism ** | Alanine, aspartate and glutamate metabolism |
| D-Glutamine and D-glutamate metabolism ** | Arginine biosynthesis |
| beta-Alanine metabolism ** | Glycerophospholipid metabolism |
| Butanoate metabolism | |
| Sphingolipid metabolism | |
| TOF/DORV, RVOT stenosis | |
| Arginine biosynthesis *** | |
| Aminoacyl-tRNA biosynthesis *** | |
| Histidine metabolism * | |
| D-Glutamine and D-glutamate metabolism * | |
| Arginine and proline metabolism * | |
| Taurine and hypotaurine metabolism | |
| Phenylalanine metabolism | |
| Alanine, aspartate and glutamate metabolism | |
| Pantothenate and CoA biosynthesis |
Abbreviations: FDR—false discovery rate; TOF—Tetralogy of Fallot; DORV—double outlet right ventricle; RVOT—right ventricular outflow tract.