Figure 2.

Effect of ellagic acid on the threshold for the onset of the first myoclonic twitch (A), generalized clonus (B), and forelimb tonus (C) in the i.v. PTZ seizure threshold test in mice. Ellagic acid and valproate (positive control) were injected i.p. 60 and 15 min before the test, respectively. The doses are shown on the abscissa. Control animals received 0.5% methylcellulose. Data are expressed as means (mg/kg PTZ) ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. the control group (one-way ANOVA followed by Dunnett’s post hoc test).