Figure 3.

Effect of ellagic acid on the seizure threshold in the MEST test in mice. Ellagic acid and valproate (positive control) were injected i.p. at 60 and 15 min before the test, respectively. The doses are shown on the abscissa. Control animals received 0.5% methylcellulose. Data are expressed as CS₅₀ (in mA) values with 95% confidence limits. Each CS₅₀ value represents the current intensity predicted to produce convulsions in 50% of mice. * p < 0.05, *** p < 0.001 vs. the control group (one-way ANOVA followed by Dunnett’s post hoc test).