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ROI or 5-LOX inhibitors blocked NF-κB activation by IL-1β in a cell-specific manner. Nuclear extracts were prepared from Raji (A), U937 (B), THP-1 (C), HCT116 (D), or MCF7 A/Z (E) cells, either untreated or stimulated with IL-1β (50 U/ml). The same cells were preincubated prior to IL-1β stimulation with increasing concentrations of NAC, PDTC, MK886, or ETYA, as indicated in the figure. These extracts were analyzed by EMSA for binding to a specific κB probe.
