Table 1.
Characteristics of the included studied in detail.
| Author, Year | Country | No. of Randomized Participants | Study Design | Study Comparison | Gender | |
|---|---|---|---|---|---|---|
| Male | Female | |||||
| Koletar SL et al., 1990 | NM | 36 | RCT | Fluconazole s 100 mg OD vs. Clotrimazole t 10 mg 5× Daily day | 33 | 3 |
| Smith DE et al., 1991 | UK | 85 | RCT | Itraconazole s 200 mg OD vs. Ketoconazole s 200 mg BD | 85 | 0 |
| Redding S.W. et al., 1992 | US | 24 | RCT | Fluconazole s 100 mg OD vs. Clotrimazole t 10 mg 5× Daily | 24 | 0 |
| De Wit S et al., 1993 | NM | 56 | RCT | Single dose Fluconazole s 150 mg vs. Daily Fluconazole s 50 mg | NM | NM |
| Pons V et al., 1993 | NM | 334 | RCT | Fluconazole s 100 mg OD vs. Clotrimazole t 10 mg 5× a day | 308 | 26 |
| de Repentigny L et al., 1996 | Canada | 106 | RCT | Itraconazole s 200 mg OD vs. Ketoconazole s 200 mg OD | 93 | 5 |
| De Wit S et al., 1997 | Belgium, UK, France | 27 | RCT | D0870 s(100 mg/25 mg) vs. D0870 s (10 mg/10 mg) | 23 | 4 |
| Murray PA et al., 1997 | US | 162 | RCT | Itraconazole s 200 mg OD vs. Clotrimazole t 10 mg 5× a day | 120 | 29 |
| Pons V et al., 1997 | US | 167 | RCT | Fluconazole s 100 mg OD vs. Nystatin t 500,000 U QID | NM | NM |
| De Wit S et al., 1998 | Belgium | 40 | RCT | Single dose Fluconazole s 150 mg vs. Itraconazole s 100 mg OD | 32 | 8 |
| Graybill JR et al., 1998 | US | 190 | RCT | Itraconazole s 200 mg OD vs. Fluconazole s 100 mg OD | 166 | 13 |
| Phillips P et al., 1998 | Austria, Belgium, Canada, Germany, Netherlands, Spain, UK | 244 | RCT | Itraconazole s 100 mg OD/BD vs. Fluconazole s 100 mg OD | 221 | 23 |
| Linpiyawan R et al., 2000 | Thailand | 29 | RCT | Clotrimazole t 10 mg 5× Daily vs. Itraconazole s 100 mg BD | 20 | 9 |
| Vazquez JA et al., 2002 | US | 25 | RCT | Alcohol-based Melaleuca t 15 mL QID vs. Alcohol-free Melaleuca t 5 mL QID | 25 | 0 |
| Van Roey J et al., 2004 | Uganda | 357 | RCT | Miconazole t 10 mg OD vs. Ketoconazole s 400 mg OD | 82 | 275 |
| Vazquez JA et al., 2006 | US, Europe, Latin America, Canada, South Africa | 350 | RCT | Posaconazole s 200 mg Day 1, 100 mg OD vs. Fluconazole s 200 mg Day 1, 100 mg OD | 262 | 88 |
| Hamza OJM et al., 2008 | Tanzania | 220 | RCT | Single dose Fluconazole s 750 mg vs. Daily Fluconazole s 150 mg OD | 53 | 167 |
| Wright S.C. et al., 2009 | South Africa | 90 | RCT | Gentian violet t 0.5% TDS vs. Lemon juice t TDS vs. Lemongrass t BD | 22 | 60 |
| Vazquez JA et al., 2010 | US, Canada, South Africa | 578 | RCT | Miconazole t 10 mg OD vs. Clotrimazole t 10 mg 5× Daily | 236 | 341 |
| Mukherjee PK et al., 2017 | South Africa, India, Uganda, Kenya, Botswana, Malawi, Zimbabwe | 221 | RCT | Gentian violet t 0.00165% BD vs. Nystatin t 500,000 U QID | 93 | 128 |
Abbreviations: NM, not mentioned; RCT, randomized control trial, OD, once daily, BD, twice a day, TDS, three times a day, QID, four times a day, t topical, s systemic.