Table 6.
In vitro aerosol dispersion performance as DPIs (n = 3, mean ± standard deviation).
| Powder Formulation Composition (Molar Ratio) | Emitted Dose (ED) (%) | Fine Particle Fraction (FPF) (%) | Respirable Fraction (RF) (%) | MMAD (μm) |
GSD |
|---|---|---|---|---|---|
| Raw Ang (1—7) | 100.74 ± 2.69 | 7.75 ± 0.44 | 60.75 ± 0.48 | 5.53 ± 0.91 | 7.06 ± 0.75 |
| Raw PNA5 | 101.52 ± 5.91 | 3.33 ± 0.15 | 41.26 ± 0.76 | 9.01 ± 0.64 | 2.89 ± 0.21 |
| SD Ang (1—7) | 79.80 ± 2.06 | 44.45 ± 3.85 | 97.35 ± 2.00 | 1.72 ± 0.03 | 1.76 ± 0.07 |
| SD PNA5 | 64.45 ± 1.73 | 50.52 ± 8.18 | 96.93 ± 2.39 | 1.99 ± 0.06 | 1.97 ± 0.17 |
| Co-SD Ang (1—7): Trehalose 25:75 | 83.70 ± 1.53 | 50.21 ± 1.58 | 95.71 ± 1.57 | 1.70 ± 0.08 | 1.81 ± 0.10 |
| Co-SD PNA5: Trehalose 25:75 | 86.26 ± 0.22 | 32.49 ± 0.28 | 91.26 ± 0.31 | 2.09 ± 0.02 | 1.81 ± 0.03 |