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. 2021 Jul 27;13(8):2570. doi: 10.3390/nu13082570

Figure 5.

Figure 5

Genes related to bone formation and bone resorption in mice that were sham operated or ovariectomized and untreated or administered EV, LVK, or HVK for 12 weeks. The mRNA expression of Runx2 (A), Osx (B), Tgfb (C), Bmp2 (D), Mitd (E), Pu.1 (F), Nfatc1 (G), Akt1 (H), Rankl (I), Opg (J), Opg/Rankl (K). Values are mean ± SD, n = 5–6 per treatment. Labeled without a common letter means a significant difference, p < 0.05. EV, estradiol valerate; HVK; MK-4 40 mg/kg body weight group; LVK, MK-4 20 mg/kg body weight group; MK-4, menaquinone-4; OVX, ovariectomized group; SD, standard deviation.