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. 2021 Aug 23;9(8):1787. doi: 10.3390/microorganisms9081787

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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HBV DNA integration density plots for the chromosomes 1–7 and 19 in which the recurrently affected genes are localized. The yellow density plots represent the density of integrations per 1 Mbp (1,000,000 bp) through the chromosome that are referring to coding genomic regions, while the blue density plots represent the density of integrations per 1 Mbp that are referring to all genomic regions (coding and non-coding). The mean values are depicted via the horizontal dashed lines, and the locations of the main target genes are also present. The plots were generated with the karyoploteR R package [187].