Table 5.

Cox regression uninominal analysis of OS according to the examined variables.

	HR	95% CI	p
Sex
Male *	0.636	0.32–1.28	0.206
Female
Histological type
ADC *	1.3	0.8–2.02	0.304
SSC
ADC subtype
Acinar *			0.016
Papillary	1.96	0.7–5.5	0.203
Solid	4.2	1.6–11.4	0.004
Gradus
1 *	1.26	0.8–1.97	0.313
2
3
Lympho-vascular invasion
No *	2.15	1.17–3.98	0.015
Yes
Pathological stage
1 *	1.33	0.94–1.9	0.108
2
3
Lymph node status
Negative *	1.4	0.79–2.5	0.241
Positive
PD-L1 expression
Negative *	0.87	0.48–1.6	0.646
Positive
IMR
Absent + Low	2	0.79–5	0.142
Strong *

M—male; F—female; * level of reference IMR immune microenvironment response.