Table 2.
Brain region-specific parameter estimates for absolute volumes generated using the Gompertz model 1.
| CONT | TEST | Pooled SEM | p-Value 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROI Parameter 3 | a | b | g | a | b | g | a | b | g | a | b | g |
| Whole brain | 147,805.08 | 0.34 | 0.11 | 151,390.00 | 0.33 | 0.11 | 7221.096 | 0.021 | 0.010 | 0.634 | 0.722 | 0.987 |
| Grey matter | 60,903.83 | 0.20 | 0.11 | 62,357.33 | −0.07 | 0.13 | 5604.781 | 0.210 | 0.041 | 0.798 | 0.180 | 0.680 |
| White matter | 58,858.29 | 0.56 | 0.13 | 58,095.33 | 0.59 | 0.13 | 3168.560 | 0.027 | 0.010 | 0.812 | 0.329 | 0.515 |
| Cerebrospinal fluid |
29,378.14 | 1.13 | 0.17 | 26,629.08 | 1.09 | 0.17 | 2519.084 | 0.052 | 0.021 | 0.264 | 0.486 | 0.904 |
| Cerebral aqueduct | 82.46 | 0.04 | 0.09 | 64.92 | −0.14 | 0.15 | 14.475 | 0.173 | 0.080 | 0.238 | 0.321 | 0.488 |
| Corpus callosum | 1500.20 | 0.38 | 0.08 | 1711.90 | 0.47 | 0.07 | 391.500 | 0.081 | 0.018 | 0.594 | 0.265 | 0.707 |
| Cerebellum | 24,387.70 | 0.42 | 0.08 | 34,678.80 | 0.56 | 0.08 | 9305.100 | 0.107 | 0.018 | 0.281 | 0.215 | 0.874 |
| Fourth ventricle | 227.80 | −0.05 | 0.06 | 187.80 | −0.19 | 0.07 | 65.106 | 0.234 | 0.011 | 0.546 | 0.557 | 0.355 |
| Hypothalamus | 388.70 | 0.36 | 0.09 | 400.80 | 0.36 | 0.09 | 49.367 | 0.052 | 0.011 | 0.809 | 0.950 | 0.908 |
| Left caudate | 1102.40 | 0.32 | 0.06 | 1235.90 | 0.29 | 0.07 | 277.300 | 0.122 | 0.016 | 0.646 | 0.824 | 0.563 |
| Left hippocampus | 1388.50 | 0.41 | 0.08 | 1718.10 | 0.49 | 0.07 | 332.000 | 0.087 | 0.017 | 0.331 | 0.350 | 0.552 |
| Left inferior colliculus |
435.00 | 0.58 | 0.05 | 389.00 | 0.46 | 0.06 | 71.070 | 0.129 | 0.015 | 0.525 | 0.369 | 0.477 |
| Left internal capsule |
2021.30 | 0.26 | 0.08 | 2759.70 | 0.43 | 0.06 | 395.000 | 0.102 | 0.010 | 0.107 | 0.129 | 0.095 |
| Left olfactory bulb | 3432.50 | 0.36 | 0.09 | 3567.80 | 0.42 | 0.11 | 459.800 | 0.151 | 0.018 | 0.773 | 0.700 | 0.509 |
| Left putamen globus pallidus |
831.80 | 0.32 | 0.06 | 845.60 | 0.43 | 0.04 | 229.800 | 0.147 | 0.012 | 0.952 | 0.473 | 0.302 |
| Left superior colliculi |
1085.80 | 0.54 | 0.06 | 863.80 | 0.45 | 0.06 | 196.400 | 0.096 | 0.011 | 0.270 | 0.327 | 0.685 |
| Lateral ventricle | 2068.70 | 0.36 | 0.06 | 2330.30 | 0.43 | 0.06 | 439.900 | 0.101 | 0.019 | 0.558 | 0.471 | 0.972 |
| Medulla | 5210.30 | 0.60 | 0.08 | 8241.60 | 0.67 | 0.08 | 1995.800 | 0.149 | 0.018 | 0.d180 | 0.665 | 0.852 |
| Midbrain | 6179.30 | 0.33 | 0.09 | 6044.50 | 0.35 | 0.09 | 319.300 | 0.053 | 0.011 | 0.677 | 0.710 | 0.642 |
| Pons | 4237.10 | 0.53 | 0.08 | 3985.80 | 0.51 | 0.08 | 354.700 | 0.149 | 0.015 | 0.487 | 0.891 | 0.928 |
| Right caudate | 1256.10 | 0.39 | 0.06 | 2094.30 | 0.49 | 0.06 | 620.000 | 0.136 | 0.021 | 0.216 | 0.461 | 0.957 |
| Right hippocampus | 1152.20 | 0.37 | 0.08 | 1863.40 | 0.72 | 0.05 | 380.000 | 0.156 | 0.011 | 0.135 | 0.053 | 0.009 |
| Right inferior colliculus |
489.60 | 0.60 | 0.05 | 524.60 | 0.53 | 0.05 | 91.486 | 0.127 | 0.018 | 0.706 | 0.552 | 0.722 |
| Right internal capsule |
2134.60 | 0.34 | 0.07 | 2335.30 | 0.35 | 0.07 | 294.700 | 0.069 | 0.012 | 0.503 | 0.797 | 0.603 |
| Right olfactory bulb |
3687.60 | 0.32 | 0.20 | 3491.80 | 0.33 | 0.08 | 715.400 | 0.135 | 0.101 | 0.781 | 0.941 | 0.268 |
| Right putamen globus pallidus |
576.00 | 0.29 | 0.05 | 657.40 | 0.31 | 0.06 | 90.235 | 0.094 | 0.012 | 0.396 | 0.817 | 0.486 |
| Right superior colliculi |
811.10 | 0.41 | 0.07 | 1002.30 | 0.47 | 0.07 | 184.600 | 0.096 | 0.018 | 0.311 | 0.544 | 0.716 |
| Thalamus | 3563.40 | 0.36 | 0.06 | 3639.10 | 0.41 | 0.05 | 381.100 | 0.194 | 0.011 | 0.845 | 0.801 | 0.640 |
1 Abbreviations: CONT, control diet, ROI, region of interest; SEM, standard error of the mean; TEST, test diet. 2 p-values derived from a two-sample t-test comparing pigs provided different early-life dietary interventions. 3 Parameter estimations for each outcome were computed for maximum absolute (i.e., plateau) value (a), onset of initial developmental increase (b), and overall rate of development (g).