Table 4.
Examples of self-healing hydrogels for heart regeneration.
| Self-Healing Mechanisms | Materials | Application(s) | Ref. |
|---|---|---|---|
| Hydrogen bonds | UPy-10 k gel | Carrier of growth factors (HGF and IGF-1) for MI | [80] |
| Host-guest | HA-CD/AD | Delivery mi-RNA302 for MI ina mouse infarction model | [82] |
| Host-guest/Thiol | Adamantane-thiol-HA β-cyclodextrin-methacrylate-HA |
Tissue repair in pig model of MI | [83] |
| Photo crosslink | CNT-GELMA | Enhancing CM and stable beatine rate for MI | [84] |
| Imine bond | ALG-CHO and amine gelatine hydrogel | Improving neovascularization in MI | [85] |
| Imine bond | Mixture patch of gelatin-dopamine (GelDA) with dopamine-modified polypyrrole (DA-PPy) in hyaluronic hydrogel | Mechanical support and promoting angiogenesis MI | [86] |
| Imine bond | CS-AT-PEG-DA | Improving inflammatory reaction MI | [79] |
| Hydrazone band | ALD-HA/HA-MMP-HYD | Carrier of siRNA (MMP2) for MI in a rat infarction model | [87] |