The distribution of UPDRS ratings across the five assessment centres. Severity scores were imbalanced, with low scores being more common than high scores, reflecting the distribution of ratings commonly encountered in the clinic [30]. DCMN: Department of Clinical and Movement Neurosciences, Institute of Neurology, University College London; DRC: Dementia Research Center, Institute of Neurology, University College London; NRC: Neuroscience Research Centre, Molecular and Clinical Sciences Research Institute, St. George’s, University of London; PDMDC: Parkinson’s Disease and Movement Disorders Center, Baylor College of Medicine; TSL: The Starr Lab, University of California San Francisco.