Figure 7.

ImmTOR suppresses the induction of IgG against Anc80 vector after initial and repeat co-administrations

Groups of mice (six to nine per group at all of the following time points) were injected twice with an 8-week interval with 2.5 × 10¹² vg/kg of Anc80-MMUT alone or combined with ImmTOR (at 100 or 300 μg of rapamycin; see Figures 1, 2, 3, and 4) and Anc80 IgG in serum measured at times indicated and presented as EC₅₀. Averages with SD are shown. Statistical difference between the group treated with Anc80-MUT alone versus those treated with Anc80 combined with ImmTOR is shown for all time points (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001).