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. 2021 Jun 4;25:355–371. doi: 10.1016/j.omtn.2021.05.022

Table 2.

Diseases regulation of circular RNAs through miRNA sponging

SI no. Circular RNAs Sponged miRNA Target gene for miRNA Different diseases regulation References
1 CDR1as/ciRS-7 miR-7 Pax6 and Myrip diabetes 76
2 CDR1as/ciRS-7 miR-7 UBE2A Alzheimer’s disease 77
3 circRNA-CER miR-136 MMP13 osteoarthritis 78
4 circTCF25 miR-103a-3p and miR-107 CDK6 bladder cancer 79
5 circRNA-MYLK miR-29a VEGFA bladder cancer 80
6 hsa_circ_000984 miR-106b CDK6 colorectal cancer 81
7 hsa_circ_0020397 miR-138 TERT and PD-L1 colorectal cancer 82
8 ciRS-7 miR-7 YY1 colorectal cancer 22,83
9 ciR-SRY miR-138 TWIST2 colorectal cancer 84
10 ciR-SRY miR-138 PCNA; Bcl-2 ovarian cancer 85,86
11 ciRS-7 miR-7 IGF1R gastric cancer 87
12 CDR1as/ciRS-7 miR-7 PI3K gastric cancer 88
13 circRNA_LARP4 miR-424 LATS1 gastric cancer 89
14 ciR-SRY miR-138 H2AX lung cancer 90,91
15 ciR-SRY miR-138 APT1/2 chronic lymphocytic leukemia 92

APT1/2, acyl protein thioesterase 1/2; Bcl-2, B cell lymphoma-2; CDK6, cyclin-dependent kinase 6; H2AX, histone family 2A variant, member X; IGF1R, insulin-like growth factor 1 receptor; LATS1, large tumor suppressor kinase 1; MMP13, matrix metalloproteinase 13; Myrip, myosin VIIA and Rab interacting protein; Pax6, paired box 6; PCNA, proliferating cell nuclear antigen; PD-L1, programmed death-ligand 1; PI3K, phosphoinositide 3-kinase; TERT, telomerase reverse transcriptase; TWIST2, twist basic helix-loop-helix transcription factor 2 gene; UBE2A, ubiquitin protein ligase A; VEGFA, vascular endothelial growth factor A; YY1, Yin Yang 1.