Table 3.

Different diseases and related circular RNAs that can be used as their probable therapeutic potential

Sl no.	Different diseases	Related circular RNAs (probable therapeutic potential)	Remark/inhibition/regulation type	References
1	lung cancer	cirITCH	downregulation	135
2	gastric cancer	hsa_circ_002059	downregulation	136
3	hepatocellular carcinoma	circ_0067934	–	137
4	cervical squamous cell carcinoma	circCDKN2B-AS1	interacts with IMP3	138
5	renal cell carcinoma	circRNA_001287	targets through miR-144-targeted CEP55	139
6	bladder carcinoma	hsa_circRNA_100876	interacts with mir-136-5p, and with mRNA-chromobox 4 (CBX4) subsequently	140
7	coronary artery disease	hsa_circ_0124644	upregulated	141
8	alzheimer’s disease	ciRS-7	upregulates UBE2A	77
9	diabetes	ciRS-7	inhibits miR-7 function in islet β cells	142
10	allergic asthma	hsa_circ_0002594	upregulated in T helper 2-mediated allergic asthma	143
11	schizophrenia	hsa_circRNA_104597	downregulated	144
12	metabolic dysfunction-associated fatty liver disease (MAFLD)	circScd1	upregulated and circScd1 influences JAK2/STAT5 signaling	145
13	hepatocellular carcinoma (HCC)	has_circ_0078710	upregulated and interacts with miR-31/HDAC and CDK2 signaling	146
14	hepatocellular carcinoma (HCC)	circMAT2B	upregulated and interacts with miR-338-3p/PKM2 signaling	147
15	fibrosis	mmu_circ_34116	downregulation; increases α-SMA expression	148
16	fibrosis	hsa_circ_0070963	downregulation; regulates miR-223-3p/LEMD3 signaling	149
17	fibrosis	circMTO1	downregulation; regulates miR-17-5p/Smad7 signaling	150
18	fibrosis	circ-PWWP2A	upregulated; regulates miR-203 and miR-223/TGF-β and LPS signaling	151
19	axial spondyloarthritis	hsa_circ_0079787	it is positively correlated with the plateletcrit (PCT) and negatively correlated with the mean platelet volume (MPV)	152
20	atherosclerosis	hsa_circ_0003575	upregulated; regulates oxLDL-induced vascular endothelial cells	153