Table 1.
Significantly enriched GO terms detected by GO enrichment analysis of each gene cluster
| ID | Term | p Value |
|---|---|---|
| Gene cluster no. 1 | ||
| GO:0070062 | extracellular exosome | 4.88E−08 |
| GO:0072562 | blood microparticle | 5.87E−08 |
| GO:0006955 | immune response | 4.04E−07 |
| GO:0019825 | oxygen binding | 1.78E−06 |
| GO:0009897 | external side of plasma membrane | 2.82E−06 |
| GO:0009986 | cell surface | 4.52E−06 |
| GO:0031295 | T cell costimulation | 6.21E−06 |
| GO:0042613 | MHC class II protein complex | 6.36E−06 |
| GO:0006954 | inflammatory response | 6.64E−06 |
| GO:0020037 | heme binding | 8.68E−06 |
| GO:0008202 | steroid metabolic process | 1.56E−05 |
| GO:0017144 | drug metabolic process | 1.97E−05 |
| GO:0042737 | drug catabolic process | 3.86E−05 |
| GO:0003823 | antigen binding | 4.49E−05 |
| GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 5.17E−05 |
| Gene cluster no. 2 | ||
| GO:0007165 | signal transduction | 1.07E−05 |
| GO:0006955 | immune response | 1.77E−04 |
| GO:0005102 | receptor binding | 7.54E−04 |
| GO:0070062 | extracellular exosome | 1.19E−03 |
| GO:0009887 | organ morphogenesis | 1.76E−03 |
| GO:0005615 | extracellular space | 1.78E−03 |
| GO:0060575 | intestinal epithelial cell differentiation | 1.79E−03 |
| GO:0005164 | tumor necrosis factor receptor binding | 2.83E−03 |
| GO:0006954 | inflammatory response | 3.17E−03 |
| GO:0006935 | chemotaxis | 5.94E−03 |
| GO:0006805 | xenobiotic metabolic process | 6.28E−03 |
| GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 6.41E−03 |
| GO:0050892 | intestinal absorption | 7.43E−03 |
| GO:0005125 | cytokine activity | 7.92E−03 |
| GO:0006366 | transcription from RNA polymerase II promoter | 9.30E−03 |
| Gene cluster no. 3 | ||
| GO:0005515 | protein binding | 5.01E−03 |
| GO:0031014 | troponin T binding | 7.09E−03 |
| GO:0014883 | transition between fast and slow fiber | 1.33E−02 |
| GO:0005861 | troponin complex | 1.44E−02 |
| GO:0016540 | protein autoprocessing | 2.45E−02 |
| GO:0006937 | regulation of muscle contraction | 2.64E−02 |
| GO:0050750 | low-density lipoprotein particle receptor binding | 2.81E−02 |
| GO:0003009 | skeletal muscle contraction | 4.48E−02 |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 4.66E−02 |
| GO:0030049 | muscle filament sliding | 7.00E−02 |
| GO:0007154 | cell communication | 7.00E−02 |
| GO:0030326 | embryonic limb morphogenesis | 7.35E−02 |
| GO:0043621 | protein self-association | 7.87E−02 |
| GO:0009267 | cellular response to starvation | 8.59E−02 |
| GO:0042277 | peptide binding | 9.98E−02 |
| Gene cluster no. 4 | ||
| GO:0005615 | extracellular space | 1.56E−04 |
| GO:0005576 | extracellular region | 2.73E−03 |
| GO:0005887 | integral component of plasma membrane | 4.59E−03 |
| GO:0060326 | cell chemotaxis | 8.09E−03 |
| GO:0070062 | extracellular exosome | 1.34E−02 |
| GO:0005578 | proteinaceous extracellular matrix | 1.45E−02 |
| GO:0007267 | cell-cell signaling | 1.57E−02 |
| GO:0005886 | plasma membrane | 1.58E−02 |
| GO:0007165 | signal transduction | 3.11E−02 |
| GO:0055114 | oxidation-reduction process | 3.37E−02 |
| GO:0005520 | insulin-like growth factor binding | 3.57E−02 |
| GO:0008285 | negative regulation of cell proliferation | 4.89E−02 |
| GO:0043066 | negative regulation of apoptotic process | 6.83E−02 |
| GO:0008284 | positive regulation of cell proliferation | 7.23E−02 |
| GO:0043407 | negative regulation of MAP kinase activity | 7.24E−02 |
| Gene cluster no. 5 | ||
| GO:0005576 | extracellular region | 4.11E−08 |
| GO:0005615 | extracellular space | 6.28E−07 |
| GO:0070062 | extracellular exosome | 1.04E−06 |
| GO:0030198 | extracellular matrix organization | 7.02E−06 |
| GO:0072562 | blood microparticle | 7.90E−06 |
| GO:0010951 | negative regulation of endopeptidase activity | 1.74E−05 |
| GO:0001523 | retinoid metabolic process | 5.56E−05 |
| GO:0030195 | negative regulation of blood coagulation | 6.25E−05 |
| GO:0005509 | calcium ion binding | 1.16E−04 |
| GO:0034364 | high-density lipoprotein particle | 4.01E−04 |
| GO:0006810 | Transport | 5.73E−04 |
| GO:0033344 | cholesterol efflux | 6.13E−04 |
| GO:0002576 | platelet degranulation | 6.54E−04 |
| GO:0042632 | cholesterol homeostasis | 9.05E−04 |
| GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway | 9.22E−04 |
| Gene cluster no. 6 | ||
| GO:0070062 | extracellular exosome | 1.93E−07 |
| GO:0005615 | extracellular space | 2.82E−04 |
| GO:0005215 | transporter activity | 5.79E−04 |
| GO:0031526 | brush border membrane | 2.04E−03 |
| GO:0016021 | integral component of membrane | 3.21E−03 |
| GO:0005903 | brush border | 3.25E−03 |
| GO:0031528 | microvillus membrane | 3.91E−03 |
| GO:0005385 | zinc ion transmembrane transporter activity | 5.55E−03 |
| GO:0055085 | transmembrane transport | 8.34E−03 |
| GO:0090675 | intermicrovillar adhesion | 1.02E−02 |
| GO:0005576 | extracellular region | 1.20E−02 |
| GO:0005886 | plasma membrane | 1.28E−02 |
| GO:0016324 | apical plasma membrane | 1.46E−02 |
| GO:0044214 | spanning component of plasma membrane | 1.47E−02 |
| GO:0030199 | collagen fibril organization | 1.70E−02 |
GO enrichment analysis was performed based on the functions of each of the gene clusters obtained by hierarchical clustering (Figure 6A). The list of genes contained in each cluster was input into DAVID (https://david.ncifcrf.gov/summary.jsp), and 15 of the outputs are shown in this table. MHC, major histocompatibility complex; MAP, mitogen-activated protein.