Table 3.
Examples of mucoadhesive buccal films based on their therapeutic category.
| Therapeutic Classification |
Polymer/Plasticizer | Active Ingredient | Manufacturing Method | Comments | References |
|---|---|---|---|---|---|
| Antihypertensive | Chitosan, polyvinylpyrrolidone, PVA, gelatin/propylene glycol | Propranolol HCl | Solvent casting | Personalized bilayered buccal film useful for pediatric population | [95] |
| Antifungal | Dextran, maltodextrin, HPMC, HPC/PEG 400 and glycerol | Amphotericin B | Solvent casting | Mechanical strength of the film was contributed by Avicel 200 and Avicel CL611 Physically stable orodispersible film was effective in oropharyngeal candidiasis |
[96] |
| Antiepileptic | HPMC | Diazepam | * | Soluble film formulation of diazepam (Libervant™) effective in acute seizure emergencies Dose can be adjusted by cutting the film of suitable size |
[97] |
| Antiprotozoal/anti-inflammatory | HPMC, PVA, chitosan/glycerin | Ornidazole and dexamethasone sodium phosphate | Solvent casting | Double layered film demonstrated >95% drug release in 4 h Significant effect on mucosal repair and reduced ulcer inflammation |
[98] |
| Anesthetic/analgesic and anti-inflammatory/ mucolytic |
HPMC, NaCMC, Chitosan/propylene glycol and sorbitol | Lidocaine HCl, benzydamine HCl, N-acetyl-cysteine | Solvent casting | Biocompatible bilayered mucoadhesive film stimulates cell proliferation and demonstrated therapeutic effect in buccal mucositis | [99] |
| Anti-inflammatory | HPMC, ethyl cellulose, chitosan, NaCMC, carbopol 971P/propylene glycol, PEG 8000 | Fluticasone propionate | Solvent casting | Optimized formulation exhibited sustained drug release for 10 h Enhanced pharmacokinetic parameters was demonstrated compared to equivalent dose of mouthwash |
[100] |
* Undisclosed.