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Spontaneous mutation rates in homozygous diploid strains measured as the rate of reversion of his7-2 or lys2::insE-A14 to His+ or Lys+, respectively
| Strain genotype | Relative reversion ratea
|
|
|---|---|---|
| his7-2 | lys2::insE-A14 | |
| POL+/POL+ | ||
| Absolute (109) | 13 | 600 |
| Relative | 1 | 1 |
| pol3-01/pol3-01 | 454 | 200 |
| exo1/exo1 | 10 | 38 |
| msh2/msh2 | 85 | 6,000 |
| pol3-01/pol3-01 exo1/exo1 | 8,460 | 4,500 |
| pol3-01/pol3-01 msh2/msh2 | 21,310 | 5,670 |
Fold increase over the wild type.
