Table 3.

Comparison of pharmacokinetic parameters before (control) and after omeprazole administration to healthy volunteers. Data are expressed as the mean ± SD and median. NA= not available * p < 0.05 vs. control; ** p< 0.001.

			Control				Omeprazole
Subject	Tlag (min)	Tmax (min)	Cmax (µg/m)	AUC0–60 (µg min/mL)	AUC0–300 (µg min/mL)	T50 (min)	GRT (min)	Tlag (min)	Tmax (min)	Cmax (µg/mL)	AUC0–60 (µg min/mL)	AUC0–300 (µg min/mL)	T50 (min)	GRT (min)
1	18.00	90.00	1.99	38.76	500.91	7.00	35.00	12.00	120.00	7.64	32.99	527.69	10.00	45.00
2	15.00	150.00	1.69	37.28	420.08	10.00	40.00	NA	0	0	0	0	NA	35.00
3	18.00	120.00	2.49	59.759	556.34	7.00	45.00	NA	0	0	0	0	NA	40.00
4	18.00	150.00	2.42	18.90	534.65	8.00	40.00	45.00	180.00	1.83	18.86	512.21	NA	35.00
5	30.00	90.00	2.57	55.35	531.90	23.00	45.00	NA	0	0	0	0	NA	75.00
6	15.00	90.00	2.80	83.36	506.36	12.00	105.00	150.00	240.00	2.68	5.31	305.61	NA	120.00
7	15.00	120.00	3.10	62.49	718.44	10.00	120.00	21.00	120.00	5.42	54.39	773.49	10.00	120.00
8	24.00	120.00	1.55	27.72	345.15	18.00	60.00	NA	0	0	0	0	NA	40.00
9	24.00	90.00	1.91	26.52	545.47	15.00	40.00	45.00	150.00	3.09	21.09	507.09	NA	35.00
10	18.00	120.00	2.20	40.62	484.92	12.00	45.00	45.00	90.00	2.46	14.09	452.09	NA	35.00
11	18.00	120.00	1.80	27.86	353.96	8.00	35.00	NA	0	0	0	0	NA	50.00
12	18.00	120.00	1.52	36.68	363.83	10.00	45.00	15.00	90.00	9.55	35.58	441.03	10.00	35.00
Mean	19.25	115.00	2.17	42.76	488.50	11.67	54.58	27.75	82.5	1.333	15.19	293.3	-	55.42
SD	4.51	21.53	0.51	18.55	106.20	4.85	28.00	42.79	83.03	1.25	18.02	279	-	32.22
Median	18.00	120.00	2.09	38.02	503.60	10.00	45.00	13.5	90.00	1.86	9.7	373.3	-	40.00
IQ	15.75-22.5	90-120	1.718-2.55	27.76–57.03	377.9–543		40–56.25	0–45	0–142.5	0–2.173	0–30.02 **	0–510.9 *		35–98.75