Table 2.
AGREE II domain scores for the 12 guidelines, after a blind evaluation by two appraisers.
| Guidelines | Scope and Purpose | Stakeholder Involvement | Rigor of Development | Clarity of Presentation | Applicability | Editorial Independence | Overall Assessment | Recommended |
|---|---|---|---|---|---|---|---|---|
| ILADS [27] | 100% | 69% | 58% | 22% | 31% | 13% | 42% | N |
| PSEID [20] | 81% | 31% | 10% | 58% | 44% | 29% | 33% | N |
| SSID and SSN [17] | 100% | 58% | 89% | 67% | 81% | 67% | 83% | Y |
| BAPCOC [26] | 72% | 50% | 40% | 67% | 71% | 58% | 53% | YM |
| AWMF [24] | 100% | 100% | 96% | 86% | 81% | 100% | 100% | Y |
| ESGBOR [18] | 75% | 58% | 66% | 42% | 44% | 79% | 50% | YM |
| HAS [22] | 100% | 100% | 88% | 83% | 79% | 54% | 75% | YM |
| NICE [23] | 100% | 100% | 94% | 89% | 100% | 100% | 100% | Y |
| AWMF [25] | 100% | 100% | 98% | 89% | 94% | 100% | 100% | Y |
| French scientific societies [7] | 100% | 100% | 99% | 87% | 92% | 100% | 100% | Y |
| Canada [21] | 64% | 36% | 17% | 39% | 85% | 42% | 25% | N |
| IDSA [19] | 100% | 100% | 100% | 63% | 94% | 96% | 100% | Y |
| Median ± IQR | 100% ± 22% | 85% ± 46% | 88% ± 48% | 67% ± 35% | 81% ± 36% | 73% ± 52% | 79% ± 54% | |
| Cohen’s kappa | - | - | - | - | - | - | 0.90 (0.84–0.96) |
Y = yes, YM = yes with modifications, N = no, ILADS = International Lyme and Associated Diseases Society; PSEID = the Polish Society of Epidemiology and Infectious diseases, SSID = Swiss Society of Infectious Disease, SSN = Swiss Society of Neurology; BAPCOC = Belgian Antibiotic Policy Coordination Committee; AWMF = The Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften; ESGBOR = European Study Group for Lyme Borreliosis; HAS = Haute Autorité de Santé, High Health Authority; NICE = National Institute for Health and Care Excellence; IDSA = Infectious Diseases Society of America.