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. 2021 Jul 27;13(8):1144. doi: 10.3390/pharmaceutics13081144

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) PTX-ss-C₁₈ prodrug of paclitaxel (PTX) can self-assemble as nanoparticles (PSNPs) that upon functionalization of their surface with Pep-PEG-DSPE (Pep-PSNPs) target glioma cells via interleukin 13 receptor α2-mediated endocytosis, releasing PTX into the glioma cells. (b) Upon functionalization of the PSPNPs surface with CGKRK-PEG-DSPE, CGKRK-PSNPs can enter glioma cells via heparan sulphate-mediated endocytosis. In both cases, the reducing environment of tumor cells allows the cleavage of the disulfide linker and the release of the free drug into glioma cells.